Towards a Precision Medicine Approach in Psychiatry based on Individual Imputation of Genomic Features

The goal is to impute genomic features (e.g. gene/isoform expression, histone modifications, chromatin accessibility etc.) at the level of each individual for different tissues, cell types and developmental stages and associate them with phenotypic traits.

The ultimate goal of this approach is to enable a genetically-based precision medicine approach in psychiatry by clustering the patients in distinct groups, characterizing their shared predicted molecular pathway dysregulation and identifying the best treatment modality.

Lastly, imputing these features at the individual level rather than doing similar analyses on GWAS summary statistics will also empower the study of the crosstalk between neuropsychiatric disorders and/or medical comorbidities.